反応式
[OH:1][CH:2]([CH2:8]Cl)[CH2:3][CH2:4][C:5]([OH:7])=[O:6].ClCC(O)C(O)=O.[CH:17]([NH2:20])([CH3:19])[CH3:18].COC1C=C(C=CC=1OC)CCN>>[CH:17]([NH:20][CH2:8][CH:2]([OH:1])[CH2:3][CH2:4][C:5]([OH:7])=[O:6])([CH3:19])[CH3:18]参加物
5
実験手順
The procedure is repeated in all essential details, except 4-hydroxy-5-chloropentanoic acid is substituted for β-chlorolactic acid and isopropylamine is substituted for 3,4-dimethoxyphenethylamine to produce the intermediate 5-isopropylamino-4-hydroxypentanoic acid. The hydroxy and amino groups are protected as described in Example I. The resulting acid is reacted with 1-naphthol instead of phenol and the protecting groups are removed as in Example I. The resulting compound should be a short acting β-blocker.
出典と根拠
- ORDレコード
- ord-14d303843c2a4c13a782419fb3c78137
- 出典データセット
- uspto-grants-1986_08
- 特許番号
- US04604481
関連ノート
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