Acetone → N-methyl-2-(2-methylphenyl)-2-oxoacetamide
反応式
[CH3:1][N+:2]#[C-:3].[CH3:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7](Cl)=[O:8].Cl.CC(C)=[O:17]>O>[CH3:3][NH:2][C:1](=[O:17])[C:7]([C:6]1[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=1[CH3:4])=[O:8]参加物
6
反応条件
- 温度
- 60 °C
実験手順
Methyl isocyanide (0.84 ml) was added to 2-methylbenzoyl chloride (1.55 g). The mixture was stirred at 60° C. for 16 hours. Then, 5N hydrochloric acid (1.5 ml) and acetone (2 ml) were added, and the mixture was stirred at room temperature for 1.5 hours for hydrolysis. Then, water was added. The mixture was extracted with methylene chloride, washed with water and dried. The solvent was evaporated under reduced pressure to obtain the title compound as an oil (1.68 g).
後処理
- stirringthe mixture was stirred at room temperature for 1.5 hours for hydrolysis
- extractionThe mixture was extracted with methylene chloride
- washwashed with water
- customdried
- customThe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-33cb00ace74546bf936022e8d0659d2b
- 出典データセット
- uspto-grants-1995_05
- 特許番号
- US05414122
反応ノート
読み込み中…