Acetone → N-methyl-2-(2-methylphenyl)-2-oxoacetamide

HRID 36428

反応式

HRID 36428 の反応式
[CH3:1][N+:2]#[C-:3].[CH3:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7](Cl)=[O:8].Cl.CC(C)=[O:17]>O>[CH3:3][NH:2][C:1](=[O:17])[C:7]([C:6]1[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=1[CH3:4])=[O:8]

参加物

6

反応物 4

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 11646Methyl isocyanideHCID 702762-Methylbenzoyl chloride

生成物 1

HCID 15239356N-methyl-2-(2-methylphenyl)-2-oxoacetamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

Methyl isocyanide (0.84 ml) was added to 2-methylbenzoyl chloride (1.55 g). The mixture was stirred at 60° C. for 16 hours. Then, 5N hydrochloric acid (1.5 ml) and acetone (2 ml) were added, and the mixture was stirred at room temperature for 1.5 hours for hydrolysis. Then, water was added. The mixture was extracted with methylene chloride, washed with water and dried. The solvent was evaporated under reduced pressure to obtain the title compound as an oil (1.68 g).

後処理

  1. stirringthe mixture was stirred at room temperature for 1.5 hours for hydrolysis
  2. extractionThe mixture was extracted with methylene chloride
  3. washwashed with water
  4. customdried
  5. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-33cb00ace74546bf936022e8d0659d2b
出典データセット
uspto-grants-1995_05
特許番号
US05414122

関連ノート

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