Propylamine → 5-Amino-1-propyl-1H-imidazole-4-carboxamide
反応式
[NH2:1][CH:2]([C:6]#[N:7])[C:3]([NH2:5])=[O:4].[CH3:8]OC(OC)OC.[CH2:15]([NH2:18])[CH2:16][CH3:17]>C(#N)C>[NH2:7][C:6]1[N:18]([CH2:15][CH2:16][CH3:17])[CH:8]=[N:1][C:2]=1[C:3]([NH2:5])=[O:4]参加物
5
実験手順
A mixture of 2-amino-2-cyanoacetamide (2.8 g, 0.0282 mol), trimethylorthoformate (3.4 g, 0.0321 mol) and acetonitrile (55 ml) was heated under reflux for 0.75 hour, then allowed to cool. n-Propylamine (1.8 g, 0.0305 mol) was then added dropwise, and the resulting mixture stirred at ambient temperature for 36 hours. The solid which precipitated was collected by filtration and crystallised from methanol to give the title compound as a colourless solid (2.9 g, 61%), m.p. 241°-243° C. Found: C,49.67; H,7.15; N,33.64. C7 H12N4O requires C,49.98; H,7.19; N,33.31%.
後処理
- temperaturewas heated
- temperatureunder reflux for 0.75 hour
- temperatureto cool
- customThe solid which precipitated
- filtrationwas collected by filtration
- customcrystallised from methanol
出典と根拠
- ORDレコード
- ord-12e40ee7e23541c4b9a7cdf8dcd80cd1
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05734053
反応ノート
読み込み中…