1-Methoxy-2-propanol → 2-Hydroxycyclohexyloxymethoxypropane

HRID 36477

反応式

HRID 36477 の反応式
[CH3:1][O:2][CH2:3][CH:4]([OH:6])[CH3:5].[CH:7]12[O:13][CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12]2>[OH-].[Na+]>[OH:6][CH:4]([CH3:5])[CH2:3][O:2][CH2:1][O:13][CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12][CH2:7]1

参加物

4

反応物 2

HCID 79001-Methoxy-2-propanol2 回HCID 9246Cyclohexene oxide

生成物 1

HCID 677825022-Hydroxycyclohexyloxymethoxypropane収率 27.4%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide触媒

実験手順

45 g (0.5 mole) of propylene glycol methyl ether (PM), 33 g (0.33 mole) of cyclohexene oxide and 0.3 g (0.007 mole) of sodium hydroxide were charged in a 100 ml eggplant type flask equipped with a reflux tube, and a reaction was allowed to proceed under reflux at a temperature for a reflux reaction for 10 hours. Results of the analysis of the resultant reaction mixture by GC showed that the conversion of PM was 20%. Then, the obtained reaction mixture was subjected to distillation, to thereby obtain 17 g of 2-hydroxycyclohexyloxymethoxypropane, i.e., propylene glycol methyl 2-hydroxycyclohexyl ether (hereinafter referred to as "PGMHCHE"). The IR spectrum of the product is shown in FIG. 3. Other properties of the product were measured and results are shown in Table 1.

後処理

  1. customequipped with a reflux tube
  2. temperatureunder reflux at a temperature for a reflux reaction for 10 hours
  3. customResults of the analysis of the resultant
  4. customreaction mixture by GC
  5. customThen, the obtained reaction mixture
  6. distillationwas subjected to distillation

出典と根拠

ORDレコード
ord-7d7484beac2744609639badf1d0f58b5
出典データセット
uspto-grants-1995_05
特許番号
US05414144

関連ノート

読み込み中…