Phenoxyacetyl chloride → Ethyl 4-(1-oxo-2-phenoxyethylamino)butanoate

HRID 36481

反応式

HRID 36481 の反応式
Cl.[NH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7].[O:11]([CH2:18][C:19](Cl)=[O:20])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C([O-])(O)=O.[Na+]>CCOCC.O>[O:20]=[C:19]([NH:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:18][O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

6

反応物 3

HCID 69703Phenoxyacetyl chlorideHCID 516892Sodium BicarbonateHCID 126496614-Aminobutyrate ethyl hydrochloride

生成物 1

HCID 53983334Ethyl 4-(1-oxo-2-phenoxyethylamino)butanoate収率 53%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒

実験手順

To a stirred mixture of ethyl 4-aminobutanoate hydrochloride (3.4 g) and phenoxyacetyl chloride (2.76 ml) in 50 ml of Et2O and 50 ml of water was added one portion of NaHCO3 (4.2 g). After 2 hr the layers were separated and the organic phase was washed (1N HCl, brine), dried (MgSO4), and filtered. Evaporation of the solvent under vacuum gave 3.1 g (53%) of the title compound as an oil.

後処理

  1. customAfter 2 hr the layers were separated
  2. washthe organic phase was washed (1N HCl, brine)
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. customEvaporation of the solvent under vacuum

出典と根拠

ORDレコード
ord-98d2491207f3486cb4bc46f3b8953d73
出典データセット
uspto-grants-1995_05
特許番号
US05414132

関連ノート

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