Phenyl Isothiocyanate → 1-Piperazinecarbothioamide, 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-N-phenyl-

HRID 364888

反応式

HRID 364888 の反応式
[N:1]1([C:7]2[N:16]=[C:15]([NH2:17])[C:14]3[C:9](=[CH:10][C:11]([O:20][CH3:21])=[C:12]([O:18][CH3:19])[CH:13]=3)[N:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:22]1([N:28]=[C:29]=[S:30])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>O1CCOCC1>[C:22]1([NH:28][C:29]([N:4]2[CH2:5][CH2:6][N:1]([C:7]3[N:16]=[C:15]([NH2:17])[C:14]4[C:9](=[CH:10][C:11]([O:20][CH3:21])=[C:12]([O:18][CH3:19])[CH:13]=4)[N:8]=3)[CH2:2][CH2:3]2)=[S:30])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

参加物

4

反応物 2

HCID 7673Phenyl IsothiocyanateHCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline

生成物 1

HCID 30614491-Piperazinecarbothioamide, 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-N-phenyl-収率 69.9%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

In 20 ml of dioxane, there was dissolved 0.87 g. (3 mmole) of 2-piperazino-4-amino-6,7-dimethoxyquinazoline. To the resultant solution was added dropwise a solution of 0.41 g. (3 mmole) of phenylisothiocyanate dissolved in 10 ml of dioxane at room temperature. The mixture was further stirred overnight. After evaporation of the solvent, the residue was chromatographed on silica gel and eluted with 20% dioxane-chloroform to obtain 0.89 g. of the desired product.

後処理

  1. customAfter evaporation of the solvent
  2. customthe residue was chromatographed on silica gel
  3. washeluted with 20% dioxane-chloroform
  4. customto obtain 0.89 g

出典と根拠

ORDレコード
ord-04adfef2fbde4940b6b617c27477a4cd
出典データセット
uspto-grants-1986_08
特許番号
US04607034

関連ノート

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