Chlorosulfonic acid → 5-tert-Butyl-2-methoxybenzene-1-sulfonyl chloride

HRID 364890ノート

反応式

HRID 364890 の反応式
[CH3:1][C:2]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=1)([CH3:4])[CH3:3].[Cl:13][S:14](O)(=[O:16])=[O:15]>C(Cl)Cl>[CH3:4][C:2]([C:5]1[CH:10]=[C:9]([S:14]([Cl:13])(=[O:16])=[O:15])[C:8]([O:11][CH3:12])=[CH:7][CH:6]=1)([CH3:1])[CH3:3]

参加物

4

反応物 2

HCID 24638Chlorosulfonic acidHCID 94750p-tert-Butylanisole

生成物 1

HCID 132102315-tert-Butyl-2-methoxybenzene-1-sulfonyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

12.3 g (0.075 mole) of 4-(1,1-dimethylethyl)anisole, dissolved in 30 ml of methylene chloride, are added dropwise, while cooling with ice, to 16.5 ml of chlorosulfonic acid, dissolved in 20 ml of methylene chloride. The mixture is stirred for 40 minutes and is then poured into ice water. The organic phase is separated off, washed with water, dried with MgSO4 and concentrated.

後処理

  1. additionare added dropwise
  2. customThe organic phase is separated off
  3. washwashed with water
  4. dry with materialdried with MgSO4
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-9e2e5c0e0d1446c3a6f29477aee1c55f
出典データセット
uspto-grants-1986_08
特許番号
US04607030

反応ノート

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