Pyridine → N-[(5-tert-Butyl-2-hydroxyphenyl)methyl]acetamide

HRID 364896

反応式

HRID 364896 の反応式
Cl.[NH2:2][CH2:3][C:4]1[CH:9]=[C:8]([C:10]([CH3:13])([CH3:12])[CH3:11])[CH:7]=[CH:6][C:5]=1[OH:14].N1C=CC=CC=1.[C:21](Cl)(=[O:23])[CH3:22]>O1CCOCC1>[C:21]([NH:2][CH2:3][C:4]1[CH:9]=[C:8]([C:10]([CH3:11])([CH3:13])[CH3:12])[CH:7]=[CH:6][C:5]=1[OH:14])(=[O:23])[CH3:22]

参加物

5

反応物 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 212969502-(Aminomethyl)-4-tert-butylphenol hydrochloride

生成物 1

HCID 13210348N-[(5-tert-Butyl-2-hydroxyphenyl)methyl]acetamide

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

43 g (0.2 mole) of 2-aminomethyl-4-(1,1-dimethylethyl)-phenol hydrochloride are suspended in 400 ml of 1,4-dioxane, and 40 ml of pyridine are added. 40 ml (0.55 mole) of acetyl chloride are added dropwise while stirring and cooling with ice. The mixture is then stirred for 2.5 hours at 90° and poured into ice water, and the precipitate which has crystallized out is filtered off with suction.

後処理

  1. temperaturecooling with ice
  2. stirringThe mixture is then stirred for 2.5 hours at 90°
  3. customthe precipitate which has crystallized out
  4. filtrationis filtered off with suction

出典と根拠

ORDレコード
ord-dcd443eda4674388a7bbb90b3deda725
出典データセット
uspto-grants-1986_08
特許番号
US04607030

関連ノート

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