Phenylacetic Acid → Benzeneacetamide, N-(2-acetylphenyl)-

HRID 364925

反応式

HRID 364925 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH3:9].[C:11]1([CH2:17][C:18](O)=[O:19])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[C:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:1][C:18](=[O:19])[CH2:17][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:10])[CH3:9]

参加物

5

反応物 3

HCID 999Phenylacetic AcidHCID 10868DicyclohexylcarbodiimideHCID 110862'-Aminoacetophenone

生成物 1

HCID 218938Benzeneacetamide, N-(2-acetylphenyl)-

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of o-aminoacetophenone (25 g.) and phenylacetic acid (25 g.) in anhydrous methylene dichloride (200 ml.) was prepared. To that mixture was added dicyclohexylcarbodiimide (40 g.) in portions of approx. 10 g. every 5 min. at ambient temperature. When the addition was completed the mixture was stirred for 4 hr. at ambient temperature. The mixture was then filtered, and the filtrate was evaporated in vacuo to dryness. The residue was crystallised from cyclohexane to give o-acetyl-N-(phenylacetyl)aniline, m.p. 78°.

後処理

  1. customwas prepared
  2. customevery 5 min.
  3. customat ambient temperature
  4. additionWhen the addition
  5. customat ambient temperature
  6. filtrationThe mixture was then filtered
  7. customthe filtrate was evaporated in vacuo to dryness
  8. customThe residue was crystallised from cyclohexane

出典と根拠

ORDレコード
ord-c30de0092d444a9b9d4cc6dd5c8c2e66
出典データセット
uspto-grants-1986_08
特許番号
US04607039

関連ノート

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