2-Methylpyridine → 1-Hexyl-2-[(4-piperidino)styryl]-pyridinium bromide

HRID 365128ノート

反応式

HRID 365128 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH3:7].[Br:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[N:15]1([C:21]2[CH:28]=[CH:27][C:24]([CH:25]=O)=[CH:23][CH:22]=2)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1.N1CCCCC1>CO.CCOCC>[Br-:8].[CH2:9]([N+:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=[CH:25][C:24]1[CH:23]=[CH:22][C:21]([N:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[CH:28][CH:27]=1)[CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

参加物

7

反応物 4

HCID 79752-MethylpyridineHCID 8082PiperidineHCID 81011-BromohexaneHCID 2913544-(Piperidin-1-yl)benzaldehyde

生成物 1

HCID 704551961-Hexyl-2-[(4-piperidino)styryl]-pyridinium bromide収率 16.3%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

2-Picoline (2.79 g, 0.03 mole) and 1-bromo-hexane (5.0 g, 0.03 mole) were heated in an oil bath at 130° C. for five hours. The resulting oil was cooled and dissolved in methanol (40 ml). 4-Piperidinobenzaldehyde (5.67 g, 0.03 mole) and piperidine (0.25 ml) were added and the mixture was refluxed under nitrogen for two hours. The addition of about 100 ml of ether to the cold solution gave red crystals which were collected and washed to give 1-hexyl-2-[(4-piperidino)styryl]-pyridinium bromide (2.1 g), melting point 212°-214° C. (decomposition).

後処理

  1. temperatureThe resulting oil was cooled
  2. temperaturethe mixture was refluxed under nitrogen for two hours
  3. customgave red crystals which
  4. customwere collected
  5. washwashed

出典と根拠

ORDレコード
ord-d4ae4e84612e488d90a28cbe0a27cb90
出典データセット
uspto-grants-1986_08
特許番号
US04608379

反応ノート

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