Water → HCID 53966869、化合物

HRID 365166ノート

反応式

HRID 365166 の反応式
[N:1]1([CH:6]([CH2:10][CH2:11][CH2:12][CH3:13])[C:7](=[O:9])[CH3:8])[CH:5]=[CH:4][N:3]=[CH:2]1.[Cl:14][C:15]1[CH:16]=[C:17]([CH:20]=[CH:21][C:22]=1[Cl:23])[CH:18]=O.C(=O)([O-])[O-].[K+].[K+].O>CO>[Cl:14][C:15]1[CH:16]=[C:17]([CH:18]=[CH:8][C:7](=[O:9])[CH:6]([N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[CH2:10][CH2:11][CH2:12][CH3:13])[CH:20]=[CH:21][C:22]=1[Cl:23]

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 227103,4-DichlorobenzaldehydeHCID 13672864HCID 13672864、化合物

生成物 1

HCID 53966869HCID 53966869、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2.7 g of 3-(imidazole-1-yl)-2-heptanone and 3.0 g of 3,4-dichlorobenzaldehyde were dissolved in 50 ml of methanol. While stirring this solution under cooling with ice (0°-5° C.), 2.1 g of potassium carbonate was added. Then, the mixture was stirred at the same temperature for 7 hours. The reaction mixture was poured into water and extracted with chloroform. The extraction solution was treated by a usual method, and the obtained oily product was purified by chromatography, whereby 1-(3',4'-dichlorophenyl)-4-(imidazole-1-yl)-1-octene-3-one was obtained as an oily product.

後処理

  1. additionwas added
  2. stirringThen, the mixture was stirred at the same temperature for 7 hours
  3. extractionextracted with chloroform
  4. additionThe extraction solution was treated by a usual method
  5. customthe obtained oily product was purified by chromatography

出典と根拠

ORDレコード
ord-43345933dc784e9b803d500880524677
出典データセット
uspto-grants-1986_08
特許番号
US04608438

反応ノート

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