3,6-Dichloropyridazine → HCID 20237843、化合物

HRID 365199ノート

反応式

HRID 365199 の反応式
[Cl:1][C:2]1[N:3]=[N:4][C:5](Cl)=[CH:6][CH:7]=1.[O:9]([CH2:16][CH:17]([OH:23])[CH2:18][NH:19][CH2:20][CH2:21][NH2:22])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(N(C(C)C)C(C)C)C>C1(C)C=CC=CC=1>[O:9]([CH2:16][CH:17]([OH:23])[CH2:18][NH:19][CH2:20][CH2:21][NH:22][C:5]1[N:4]=[N:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参加物

5

反応物 3

HCID 673313,6-DichloropyridazineHCID 81531DiisopropylethylamineHCID 145507661-[(2-Aminoethyl)amino]-3-phenoxypropan-2-ol

生成物 1

HCID 20237843HCID 20237843、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 3.0 g. 3,6-dichloropyridazine, 4.2 g. 1-phenoxy-3-(2-aminoethylamino)-propan-2-ol, 3.5 ml. N-ethyldiisopropylamine and 30 ml. toluene is stirred for 24 hours at 100° C. The reaction mixture is then evaporated and the residue is digested simultaneously with 100 ml. water and 100 ml. methylene chloride, followed by suction filtration and recrystallization from isopropyl alcohol, with treatment with fullers' earth. There are obtained 1.4 g. (21% of theory) of the desired product in the form of colorless crystals; m.p. 147°-149° C.

後処理

  1. additionA mixture of 3.0 g
  2. customThe reaction mixture is then evaporated
  3. filtrationmethylene chloride, followed by suction filtration and recrystallization from isopropyl alcohol, with treatment with fullers' earth
  4. customThere are obtained 1.4 g

出典と根拠

ORDレコード
ord-e1b8b2da957a46dc8f9bbb3b24e0fce7
出典データセット
uspto-grants-1986_08
特許番号
US04608383

反応ノート

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