Sodium Hydroxide → Piperazin-1-yl(quinolin-2-yl)methanone
反応式
Cl.[N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1)=[O:13].[OH-].[Na+]>O>[N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1)=[O:13]参加物
4
実験手順
1-(2-Quinolylcarbonyl)piperazine hydrochloride (6.18 g, 22.2 mmol) was dissolved in water. The thus-obtained solution was rendered basic with a concentrated aqueous solution of sodium hydroxide. The resulting mixture was extracted with chloroform, and the extract was washed with an aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate. The solvent was distilled off, whereby 4.236 g of the title compound were obtained as a colorless oil (yield: 79.1%).