Bromomethyl 4-methoxyphenyl ketone → 2-Bromo-1-(4-methoxyphenyl)ethan-1-ol
反応式
[BH4-].[Na+].[Br:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1)=[O:6]>CO>[Br:3][CH2:4][CH:5]([C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1)[OH:6]参加物
4
実験手順
0.826 g (21.8 mmol) of sodium borohydride was added to 2-bromo-4'-methoxy-acetophenone (10 g, 43.7 mmol) in methanol (200 ml) and the mixture was stirred for 1 hour at room temperature. The mixture was concentrated in vacuo and saturated aqueous sodium chloride was added to the residue and the product was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and concentrated in vacuo to give 2-bromo-1-(4'-methoxyphenyl)ethanol (11.05 g).
後処理
- concentrationThe mixture was concentrated in vacuo and saturated aqueous sodium chloride
- additionwas added to the residue
- extractionthe product was extracted with ethyl acetate
- washThe organic layer was washed with saturated aqueous sodium chloride
- dry with materialdried over anhydrous magnesium sulfate
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-96b1c52b41ef42a59bdca00f24fafa21
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06127361
反応ノート
読み込み中…