4-(1-Methylpyrrol-2-ylmethyl)nitrobenzene → 4-(1-Methylpyrrol-2-yl-methyl)aniline
反応式
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=1>C(OCC)(=O)C.[Pd]>[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][C:8]1[CH:9]=[CH:10][C:11]([NH2:14])=[CH:12][CH:13]=1参加物
4
実験手順
4-(1-Methylpyrrol-2-ylmethyl)nitrobenzene (500 mg, 2.31 mmol) [prepared as described in Example 21, Step (b)], was dissolved in ethyl acetate and subjected to hydrogenation over 5% Pd/C (50 mg) at ambient temperature and atmospheric pressure. After 3 h the mixture was filtered and the filtrate was concentrated to give 4-(1-methylpyrrol-2-yl-methyl)aniline (430 mg, 100%) as a yellow oil. ##STR63##
後処理
- filtrationAfter 3 h the mixture was filtered
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-7750102a0099436c9283fccd80d31ac0
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06127402
反応ノート
読み込み中…