Bromoacetyl chloride → 4-Bromoacetyl-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine

HRID 36565

反応式

HRID 36565 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:12][CH2:11][CH2:10][NH:9][CH2:8][C:7]=2[CH:13]=1.[Br:14][CH2:15][C:16](Cl)=[O:17]>C(N(CC)CC)C>[Br:14][CH2:15][C:16]([N:9]1[CH2:8][C:7]2[CH:13]=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=2[S:12][CH2:11][CH2:10]1)=[O:17]

参加物

4

反応物 2

HCID 89602Bromoacetyl chlorideHCID 118056287-Methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine

生成物 1

HCID 152916454-Bromoacetyl-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine収率 51.5%

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

7-Methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (3.0 g), triethylamine (3.1 g) and bromoacetyl chloride (3.2 g) were reacted in the same manner as in Experimental Example 1 to give 4-bromoacetyl-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (2.5 g).

出典と根拠

ORDレコード
ord-f2d9bc7a547848ad9da613d6416d1ac8
出典データセット
uspto-grants-1995_05
特許番号
US05416066

関連ノート

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