Heptanedinitrile → 2-Aminocyclohex-1-ene-1-carbonitrile
反応式
[C:1]([CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]#[N:9])#[N:2].[H-].[Na+]>O>[NH2:2][C:1]1[CH2:3][CH2:4][CH2:5][CH2:6][C:7]=1[C:8]#[N:9]参加物
4
実験手順
1,5-Dicyanopentane (Aldrich Chemicals) (25.0 g, 205 mmol), sodium hydride (60% oil dispersion; 8.2 g, 205 mmol) and T.H.F. (150 ml) were heated under reflux for 17 hours. After cooling, water (150 ml) was added and the upper organic layer removed, dried (Na2SO4) filtered and the solvent evaporated. Recrystallisation from hot toluene (80° C.) gave the product as beige crystals.
後処理
- temperature(150 ml) were heated
- temperatureunder reflux for 17 hours
- temperatureAfter cooling
- customthe upper organic layer removed
- dry with materialdried (Na2SO4)
- filtrationfiltered
- customthe solvent evaporated
- customRecrystallisation from hot toluene (80° C.)
出典と根拠
- ORDレコード
- ord-c54ede75b2ad4a5c849208ca430985ff
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06130228
反応ノート
読み込み中…