Acetic Acid → HCID 22448959、化合物

HRID 366456ノート

反応式

HRID 366456 の反応式
[OH:1][C:2]1[C:7]2[CH2:8][CH2:9][CH2:10][C:11](=[O:13])[NH:12][C:6]=2[CH:5]=[CH:4][CH:3]=1.[C:14](O)(=[O:16])[CH3:15]>N1C=CC=CC=1>[C:14]([O:1][C:2]1[C:7]2[CH2:8][CH2:9][CH2:10][C:11](=[O:13])[NH:12][C:6]=2[CH:5]=[CH:4][CH:3]=1)(=[O:16])[CH3:15]

参加物

4

反応物 2

HCID 176Acetic AcidHCID 99422906-Hydroxy-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

生成物 1

HCID 22448959HCID 22448959、化合物収率 87%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A suspension of 1,3,4,5-tetrahydro-6-hydroxy-2H-1-benzazepin-2-one (500 mg, 2.82 mmol) in 2.5 mL each of pyridine and acetic acid was stirred at room temperature. Excess reagents were removed under reduced pressure and the residue was triturated with CH2Cl2 to give 540 mg (87%) of 1,3,4,5-tetrahydro-6-acetoxy-2H-1-benzazepin-2-one; MS 219.

後処理

  1. customExcess reagents were removed under reduced pressure
  2. customthe residue was triturated with CH2Cl2

出典と根拠

ORDレコード
ord-70c2dc89be7249f8a3520f32da86a2e0
出典データセット
uspto-grants-2000_10
特許番号
US06130217

反応ノート

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