Phosphorus pentachloride → Pyridine-3-sulfonyl chloride

HRID 36649

反応式

HRID 36649 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([S:7]([OH:10])(=O)=[O:8])[CH:2]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:12]>C1(C)C=CC=CC=1.C1C=CC=CC=1>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([S:7]([Cl:12])(=[O:10])=[O:8])[CH:2]=1

参加物

5

反応物 2

HCID 24819Phosphorus pentachlorideHCID 694683-Pyridinesulfonic acid

生成物 1

HCID 3164136Pyridine-3-sulfonyl chloride収率 92%

試薬・触媒・溶媒 2

HCID 241Benzene溶媒HCID 1140Toluene溶媒

実験手順

3-Pyridylsulfonic acid (30 g, 0.188 mole) was added to PCl5 (46.8 g, 0.225 mole), suspended in 150 mL toluene and heated to reflux overnight. The suspension was cooled and concentrated to yield a yellow oil, which was diluted with benzene, filtered through a pad of celite and concentrated to give 30.7 g (92%) of 23-10 as a yellow oil, which was used in the next step without purification.

後処理

  1. temperatureheated
  2. temperatureto reflux overnight
  3. temperatureThe suspension was cooled
  4. concentrationconcentrated
  5. customto yield a yellow oil, which
  6. filtrationfiltered through a pad of celite
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-bf556213779245328caa8e5257c096ab
出典データセット
uspto-grants-1995_05
特許番号
US05416099

関連ノート

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