Phosphorus pentachloride → Pyridine-3-sulfonyl chloride
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([S:7]([OH:10])(=O)=[O:8])[CH:2]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:12]>C1(C)C=CC=CC=1.C1C=CC=CC=1>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([S:7]([Cl:12])(=[O:10])=[O:8])[CH:2]=1参加物
5
実験手順
3-Pyridylsulfonic acid (30 g, 0.188 mole) was added to PCl5 (46.8 g, 0.225 mole), suspended in 150 mL toluene and heated to reflux overnight. The suspension was cooled and concentrated to yield a yellow oil, which was diluted with benzene, filtered through a pad of celite and concentrated to give 30.7 g (92%) of 23-10 as a yellow oil, which was used in the next step without purification.
後処理
- temperatureheated
- temperatureto reflux overnight
- temperatureThe suspension was cooled
- concentrationconcentrated
- customto yield a yellow oil, which
- filtrationfiltered through a pad of celite
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-bf556213779245328caa8e5257c096ab
- 出典データセット
- uspto-grants-1995_05
- 特許番号
- US05416099
反応ノート
読み込み中…