Sodium hydride → 3-(2-Ethylhex-1-yl)-3-azabicyclo[3.1.0]hexane-2,4-dione

HRID 366536

反応式

HRID 366536 の反応式
[H-].[Na+].[CH:3]12[CH2:8][CH:7]1[C:6](=[O:9])[NH:5][C:4]2=[O:10].Br[CH2:12][CH:13]([CH2:18][CH3:19])[CH2:14][CH2:15][CH2:16][CH3:17]>CN(C)C=O.O>[CH2:18]([CH:13]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:12][N:5]1[C:6](=[O:9])[CH:7]2[CH:3]([CH2:8]2)[C:4]1=[O:10])[CH3:19]

参加物

6

反応物 3

HCID 24758Sodium hydrideHCID 868042-Ethylhexyl bromideHCID 37200533-Azabicyclo[3.1.0]hexane-2,4-dione

生成物 1

HCID 232899853-(2-Ethylhex-1-yl)-3-azabicyclo[3.1.0]hexane-2,4-dione

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

Sodium hydride (0.11 g) was added to a solution of 3-azabicyclo[3.1.0]hexane-2,4-dione (0.3 g) and 1-bromo-2-ethylhexane (0.52 g) in dimethylformamide (5 ml) and the resulting mixture was stirred at room temperature under a nitrogen atmosphere for 16 hours. The mixture was diluted with water (15 ml) and then extracted with toluene (20 ml). The organic extract was washed with water (15 ml), dried (MgSO4) and evaporated in vacuo. The residue was purified by Kugelrohr distillation (boiling point 140-160° C. @ 0.1 mmHg) to give the title compound as a colourless oil.

後処理

  1. extractionextracted with toluene (20 ml)
  2. extractionThe organic extract
  3. washwas washed with water (15 ml)
  4. dry with materialdried (MgSO4)
  5. customevaporated in vacuo
  6. distillationThe residue was purified by Kugelrohr distillation (boiling point 140-160° C. @ 0.1 mmHg)

出典と根拠

ORDレコード
ord-ebc6f14a1fce43f5b81d0c715a8f84cb
出典データセット
uspto-grants-2000_10
特許番号
US06130241

関連ノート

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