tert.-Butyl N-(trans-1-benzyl-4-methoxypyrrolidin-3yl)carbamate → rac-tert-butyl N-[(3R,4R)-4-methoxypyrrolidin-3-yl]carbamate

HRID 36654ノート

反応式

HRID 36654 の反応式
C([N:8]1[CH2:12][C@@H:11]([O:13][CH3:14])[C@H:10]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH3:14][O:13][C@@H:11]1[CH2:12][NH:8][CH2:9][C@H:10]1[NH:15][C:16](=[O:22])[O:17][C:18]([CH3:20])([CH3:19])[CH3:21]

参加物

4

反応物 1

HCID 15069969tert.-Butyl N-(trans-1-benzyl-4-methoxypyrrolidin-3yl)carbamate

生成物 1

HCID 15069971rac-tert-butyl N-[(3R,4R)-4-methoxypyrrolidin-3-yl]carbamate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

6.7 g (22 mmol) of tert.-butyl N-(trans-1-benzyl-4-methoxypyrrolidin-3-yl)carbamate are hydrogenated in 150 ml of methanol on 2 g of palladium-on-active charcoal (10% of Pd) under 100 bar at 100° C. The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.

後処理

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-94462c4fdb6a43548a178c056ea9d5a2
出典データセット
uspto-grants-1995_05
特許番号
US05416096

反応ノート

読み込み中…