Sodium Hydroxide → 6-Benzyl-octahydropyrrolo[3,4-b][1,4]oxazine

HRID 36657ノート

反応式

HRID 36657 の反応式
[CH2:1]([N:8]1[CH2:12][CH:11](O)[CH:10]([NH:14][CH2:15][CH2:16][OH:17])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>S(=O)(=O)(O)O.O>[CH2:1]([N:8]1[CH2:12][CH:11]2[CH:10]([NH:14][CH2:15][CH2:16][O:17]2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 19969797HCID 19969797、化合物

生成物 1

HCID 150699806-Benzyl-octahydropyrrolo[3,4-b][1,4]oxazine

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1118Sulfuric Acid溶媒

実験手順

15.6 g (66mmol) of 1-benzyl-4-hydroxy-3-(2-hydroxyethylamino)-pyrrolidine are heated under reflux in a mixture of 60 ml of concentrated sulphuric acid and 20 ml of water for 6 hours. The mixture is rendered alkaline with concentrated sodium hydroxide solution, the sodium sulphate which has precipitated is filtered off with suction and the filtrate is extracted with chloroform. The extract is dried over potassium carbonate and concentrated and the residue is distilled.

後処理

  1. customthe sodium sulphate which has precipitated
  2. filtrationis filtered off with suction
  3. extractionthe filtrate is extracted with chloroform
  4. dry with materialThe extract is dried over potassium carbonate
  5. concentrationconcentrated
  6. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-fbb9da8152d3432bb09a0df0f86dab43
出典データセット
uspto-grants-1995_05
特許番号
US05416096

反応ノート

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