Acetic Acid → 7-Azaoxindole acetic acid salt

HRID 366574ノート

反応式

HRID 366574 の反応式
Br[C:2]1(Br)[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]1=[O:11].[C:13]([OH:16])(=[O:15])[CH3:14]>C(#N)C.[Zn]>[C:13]([OH:16])(=[O:15])[CH3:14].[NH:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][N:6]=2)[CH2:2][C:3]1=[O:11]

参加物

5

反応物 2

HCID 176Acetic AcidHCID 138640943,3-Dibromo-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

生成物 1

HCID 219257347-Azaoxindole acetic acid salt収率 91%

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 6342Acetonitrile溶媒

実験手順

3,3-Dibromo-7-azaoxindole (2.9 g) was dissolved in a mixture of 20 mL of acetic acid and 30 mL of acetonitrile. To the solution was added 6.5 g of zinc dust. The mixture was stirred for 2 hrs at room temperature. The solid was filtered from the mixture and the solvent evaporated. The residue was slurried with ethyl acetate. The ethyl acetate solution containing insoluble solid was passed through a short column of silica gel. The collected ethyl acetate solution was evaporated and the residue dried under vacuum to give 1.8 g (yield 91%) of 7-azaoxindole acetic acid salt.

後処理

  1. filtrationThe solid was filtered from the mixture
  2. customthe solvent evaporated
  3. additionThe ethyl acetate solution containing insoluble solid
  4. customThe collected ethyl acetate solution was evaporated
  5. customthe residue dried under vacuum

出典と根拠

ORDレコード
ord-19192244774b4309a1ebed3c28e0d52d
出典データセット
uspto-grants-2000_10
特許番号
US06130238

反応ノート

読み込み中…