Hydrochloric Acid → HCID 19594629、化合物

HRID 36658ノート

反応式

HRID 36658 の反応式
C([N:8]1[CH2:16][CH:15]2[CH:10]([NH:11][CH2:12][CH2:13][O:14]2)[CH2:9]1)C1C=CC=CC=1.[ClH:17]>CO.[Pd]>[ClH:17].[ClH:17].[CH:15]12[CH2:16][NH:8][CH2:9][CH:10]1[NH:11][CH2:12][CH2:13][O:14]2

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 150699806-Benzyl-octahydropyrrolo[3,4-b][1,4]oxazine

生成物 1

HCID 19594629HCID 19594629、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 4 g (18.2 mmol) of 8-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane in 100 ml of methanol and 3.5 ml of concentrated hydrochloric acid is hydrogenated on 2 g of palladium-on-active charcoal (10% of Pd) at 80° C. under 100 bar. The catalyst is filtered off and washed with water. The filtrates are concentrated and the product is crystallized by trituration with a little methanol. The crystals are filtered off with suction, washed with acetone and dried in air.

後処理

  1. filtrationThe catalyst is filtered off
  2. washwashed with water
  3. concentrationThe filtrates are concentrated
  4. customthe product is crystallized by trituration with a little methanol
  5. filtrationThe crystals are filtered off with suction
  6. washwashed with acetone
  7. customdried in air

出典と根拠

ORDレコード
ord-f1973b60b0b14770b54b52dbe940f50b
出典データセット
uspto-grants-1995_05
特許番号
US05416096

反応ノート

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