HCID 15069996、化合物 → Ethyl 3-(hydroxymethyl)-4-(methylamino)pyrrolidine-1-carboxylate
反応式
[CH3:1][N:2]1[O:9][CH2:8][CH:7]2[CH:3]1[CH2:4][N:5]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:6]2>C(O)C.[Pd]>[OH:9][CH2:8][CH:7]1[CH2:6][N:5]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:4][CH:3]1[NH:2][CH3:1]参加物
4
実験手順
10 g (50 mmol) of ethyl 2-methyl-3-oxa-2,7-diazabicyclo[3.3.0]octane-7-carboxylate (Example H d)) are hydrogenated in 200 ml of ethanol on 3 g of Pd-on-active charcoal (10% of Pd) at 50° C. under 50 bar. The catalyst is filtered off, the filtrate is concentrated and the residue is distilled.
後処理
- filtrationThe catalyst is filtered off
- concentrationthe filtrate is concentrated
- distillationthe residue is distilled
出典と根拠
- ORDレコード
- ord-f07b5c5939194f8e9c893b8e33a9f4c1
- 出典データセット
- uspto-grants-1995_05
- 特許番号
- US05416096
反応ノート
読み込み中…