Oxalyl chloride → 3-Cyano-2,4,5-trifluoro-benzoyl chloride

HRID 367015ノート

反応式

HRID 367015 の反応式
[C:1]([C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6](O)=[O:7])#[N:2].C(Cl)(=O)C([Cl:18])=O>C(Cl)Cl.CN(C)C=O>[C:1]([C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6]([Cl:18])=[O:7])#[N:2]

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 18417533195532-64-0

生成物 1

HCID 186187613-Cyano-2,4,5-trifluoro-benzoyl chloride収率 97%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒2 回

実験手順

111 g of 3-cyano-2,4,5-trifluoro-benzoic acid and 84 g of oxalyl chloride are stirred at room temperature for 5 hours in 930 ml of dry methylene chloride with addition of a few drops of dimethylformamide. The methylene chloride is then stripped off and the residue is distilled in vacuo. 117.6 g of 3-cyano-2,4,5-trifluoro-benzoyl chloride are obtained as a yellow oil.

後処理

  1. distillationthe residue is distilled in vacuo

出典と根拠

ORDレコード
ord-c305de2533e74749a9a665a3cad0b132
出典データセット
uspto-grants-2000_10
特許番号
US06133260

反応ノート

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