5-Ethenyl-6-fluoropyridin-3-amine → 5-Ethyl-6-fluoropyridin-3-amine
反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH2:10])[C:5]([F:8])=[N:6][CH:7]=1>CO.[Pd]>[NH2:1][C:2]1[CH:3]=[C:4]([CH2:9][CH3:10])[C:5]([F:8])=[N:6][CH:7]=1参加物
4
実験手順
A solution of the 5-amino-2-fluoro-3-vinylpyridine from Step 126c above (2.30 g, 16.6 mmol) in MeOH (50 mL) was added to a suspension of 10% palladium on activated carbon (Aldrich, 0.10 g) in MeOH (75 ml). The mixture was placed under an atmosphere of H2 (balloon) for 48 h. The catalyst was removed by filtration and the solvent was evaporated to yield the title compound as a beige solid (2.31 g, 99%): 1H NMR (CDCl3, 300 MHz) δ 1.22 (t, J=7.5 Hz, 3H), 2.58 (q, J=7.5 Hz, 2H), 6.96 (dd, J=3.0, 5.1 Hz, 1H), 7.45 (m, 1H); MS (CI/NH3) m/z 141 (M+H)+, 158 (M+NH4)+.
後処理
- customThe catalyst was removed by filtration
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-f18e75a7be074298b61be8d4aba0b647
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06133253
反応ノート
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