Ammonium thiocyanate → HCID 23287621、化合物

HRID 367209

反応式

HRID 367209 の反応式
Cl[C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[S-:11][C:12]#[N:13].[NH4+].[CH3:15][NH:16][C:17]1[CH:21]=[CH:20][S:19][CH:18]=1>CC(C)=O>[CH3:15][N:16]([C:12]1[S:11][C:2]2[N:10]=[CH:9][CH:8]=[CH:7][C:3]=2[C:4](=[O:5])[N:13]=1)[C:17]1[CH:21]=[CH:20][S:19][CH:18]=1

参加物

5

反応物 3

HCID 15666Ammonium thiocyanateHCID 642344N-methylthiophen-3-amineHCID 27745412-Chloronicotinoyl chloride

生成物 1

HCID 23287621HCID 23287621、化合物収率 26.3%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

The reaction procedure of Example 102 was followed except that 560 mg of 2-chloronicotinoyl chloride, 242 mg of ammonium thiocyanate, 360 mg of 3-(methylamino)thiophene and 10 ml of acetone were used. The product was then recrystallized from a mixture of ethanol and chloroform to obtain 230 mg of 2-[N-methyl-N-(3-thienyl)amino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one.

後処理

  1. customThe reaction procedure of Example 102
  2. customThe product was then recrystallized from a mixture of ethanol and chloroform

出典と根拠

ORDレコード
ord-f44349c4c9634de7b3e5f2bc8b5ad0da
出典データセット
uspto-grants-2000_10
特許番号
US06133258

関連ノート

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