Hydrogen Bromide → 2-Bromo-1-(4-hydroxy-3-(hydroxymethyl)phenyl)ethan-1-one
反応式
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:14])[CH2:12][Br:13])=[CH:7][C:6]=1[CH2:15][O:16]C(=O)C)(=O)C.Br.O>CO>[Br:13][CH2:12][C:11]([C:8]1[CH:9]=[CH:10][C:5]([OH:4])=[C:6]([CH2:15][OH:16])[CH:7]=1)=[O:14]参加物
5
実験手順
2-Acetoxymethyl-4-bromoacetylphenyl acetate (18.6 g) was dissolved in 90 ml of methanol, 100 ml of 47% hydrobromic acid was added with stirring under ice-cooling, and the mixture was subjected to 16 hours of reaction at room temperature. Water was added to the reaction solution with stirring under ice-cooling, and the resulting precipitates were collected by filtration and washed with water and hexane to give 9.54 g of 2-bromo-4'-hydroxy-3'-hydroxymethylacetophenone having a melting point of 117 to 119° C.
後処理
- temperaturecooling
- customthe mixture was subjected to 16 hours of reaction at room temperature
- stirringwith stirring under ice-
- temperaturecooling
- customthe resulting precipitates
- filtrationwere collected by filtration
- washwashed with water and hexane
出典と根拠
- ORDレコード
- ord-e86e760ef26a46c2a17e06cc180d55e1
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06133266
反応ノート
読み込み中…