5-Bromoindole → 5-bromo-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole

HRID 367369ノート

反応式

HRID 367369 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[CH3:11][N:12]1[CH2:17][CH2:16][C:15](=O)[CH2:14][CH2:13]1.N1CCCC1>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:15]1[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH:14]=1

参加物

5

反応物 3

HCID 249055-BromoindoleHCID 31268PyrrolidineHCID 740491-Methyl-4-piperidone

生成物 1

HCID 149732085-bromo-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole収率 76%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

5-Bromo-1H-indole (4.31 g, 22 mmol), 1-methyl-4-piperidone (2.46 mL, 20 mmol) and pyrrolidine (17 mL, 200 mmol) were mixed in ethanol (30 mL) and refluxed for 72 hours. The mixture was cooled to room temperature and the resulting solid, collected by filtration, washed with methanol and dried to provide the title compound as a white solid (4.40 g, 76%). mp>230° C., dec.

後処理

  1. temperaturerefluxed for 72 hours
  2. filtrationthe resulting solid, collected by filtration
  3. washwashed with methanol
  4. customdried

出典と根拠

ORDレコード
ord-b7cd3a6acffc4baeb09b2ac3fbb58cd8
出典データセット
uspto-grants-2000_10
特許番号
US06133287

反応ノート

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