Hydrochloric Acid → 3-Fluoro-4-methoxyphenylboronic acid

Then, 9.6 g of magnesium was added to 230 ml of THF, and the solution thus formed was slowly added dropwise with 70.9 g of the 4-bromo-2-fluoroanisole obtained by the procedure mentioned above to prepare a Grignard reagent. The reagent was added dropwise to a mixture of 123.8 g of triisopropyl borate and 391 ml of THF at a temperature of -60° C. to -50° C. with stirring. After the dropping of the reagent was finished, the solution was subjected to reaction at an ambient temperature for 2 hours, added with 242 ml of a 1N-aqueous hydrochloric acid solution, subjected to further reaction for 1 hour, extracted with an ether, washed with water, and concentrated under a reduced pressure to obtain 46.2 g of 4-methoxy-3-fluorobenzene boronic acid.

1. customthe solution thus formed
2. customobtained by the procedure
3. customthe solution was subjected to reaction at an ambient temperature for 2 hours
4. customsubjected to further reaction for 1 hour
5. extractionextracted with an ether
6. washwashed with water
7. concentrationconcentrated under a reduced pressure

ORDレコード

ord-25b0f0e5e9c241c398e5745d30c58bb2

出典データセット

uspto-grants-1995_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05417885