Hydroxyamine hydrochloride → HCID 178513387、化合物
反応式
[ClH:1].[NH2:2][OH:3].C[O-].[Na+].Cl[C:8]1[CH:9]=[C:10]([C:15]#[N:16])[CH:11]=[N:12][C:13]=1[Cl:14]>CO>[Cl:1][C:8]1[CH:9]=[C:10]([C:15](=[NH:16])[NH:2][OH:3])[CH:11]=[N:12][C:13]=1[Cl:14]参加物
5
実験手順
Hydroxylamine hydrochloride (2.6 g, 0.038 mol) was slurried in methanol (75 mL) and sodium methoxide (2.0 g, 0.037 mol) added. The mixture was stirred for half an hour and 5,6-dichloro-3-pyridinecarbonitrile (4.3 g, 0.025 mol) added. The mixture was stirred at room temperature overnight and filtered. The precipitate was washed with water and methanol and dried to give the desired product (4.2 g, 82%) as a white solid, MP 182-184° C.
後処理
- stirringThe mixture was stirred at room temperature overnight
- filtrationfiltered
- washThe precipitate was washed with water and methanol
- customdried
出典と根拠
- ORDレコード
- ord-ec543ccb5e3a4768bbdce4c8798977de
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06133294
反応ノート
読み込み中…