Sodium Hydroxide → HCID 23288445、化合物
反応式
[OH:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[NH:11][C:12]([NH:14][CH:15]([C:19](OCC)=[O:20])[CH:16]([CH3:18])[CH3:17])=[O:13].[OH-].[Na+]>C(O)C.O>[OH:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[NH:11][C:12]([NH:14][C:15](=[C:19]=[O:20])[CH:16]([CH3:18])[CH3:17])=[O:13]参加物
4
実験手順
To a solution of N-(2-Hydroxy-4-nitrophenyl)-N'-[1-(ethoxycarbonyl)-2-methylpropyl)urea (200 mg, 0.62 mmol) in ethanol/water (10 mL/1 mL), sodium hydroxide (123 mg, 3.1 mmol) was added. The reaction mixture was stirred at reflux temperature for 16 hours. Then the reaction mixture was cooled to room temperature and all the solvent was evaporated. 3N of HCl was added to pH=1. A yellow solid precipitated, it was filtered to give desired product (86 mg, 47%). EI-MS m/z 298.3 (M+). mp: 168.4-169.2° C.