Methanol → 3,5,6-Trifluoropyridin-2-amine
反応式
CO.C([NH:10][C:11]1[C:16]([F:17])=[CH:15][C:14]([F:18])=[C:13]([F:19])[N:12]=1)C1C=CC=CC=1>[Pd].C(O)(=O)C>[NH2:10][C:11]1[C:16]([F:17])=[CH:15][C:14]([F:18])=[C:13]([F:19])[N:12]=1参加物
5
実験手順
To 40 ml of methanol were added 7.60 g of the crude 2-benzylamino-3,5,6-trifluoropyridine as described above together with 0.55 g of 10% palladium on carbon and 2 ml acetic acid, and the mixture was hydrogenated at 50° C. for one day. The catalyst was separated by filtration, and the solvent and the like were distilled off under reduced pressure. The precipitate was dispersed in n-hexane, and collected by filtration to obtain 3.85 g of the title compound as a colorless solid.
後処理
- customThe catalyst was separated by filtration
- distillationthe solvent and the like were distilled off under reduced pressure
- additionThe precipitate was dispersed in n-hexane
- filtrationcollected by filtration
出典と根拠
- ORDレコード
- ord-a71a07fba67a43aca1637d0690172013
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06133284
反応ノート
読み込み中…