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Silane, chloro(chloromethyl)dimethyl- → n,n-Diethyl-2-chloro-6-[(chloromethyl)dimethylsilyl]benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Silane, chloro(chloromethyl)dimethyl- | HCID 74393 | — |
| 反応物 | 2-Chloro-N,N-diethylbenzamide | HCID 82566 | — |
| 生成物 | n,n-Diethyl-2-chloro-6-[(chloromethyl)dimethylsilyl]benzamide | HCID 18630016 | — |
反応手順
The title compound was prepared according to General Method A from the compound of Example e and 1.5 eq (chloromethyl)dimethylsilyl chloride. Purification by HPLC using 1:9 ethyl acetate/hexanes gave 5.4 g of the desired compound as a yellow oil, an 85% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06133252 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-50db707cf0e149059d1bd51e3d57c7ab |
| 出典メモ | uspto-grants-2000_10 |