Ethoxyethylamine → N-(2-ethoxyethyl)-2-chloro-6-(trimethylsilyl)benzamide

HRID 368614

反応式

HRID 368614 の反応式
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([Si:11]([CH3:14])([CH3:13])[CH3:12])[C:3]=1[C:4](Cl)=[O:5].[CH2:15]([O:17][CH2:18][CH2:19][NH2:20])[CH3:16]>C1(C)C=CC=CC=1>[CH2:15]([O:17][CH2:18][CH2:19][NH:20][C:4](=[O:5])[C:3]1[C:7]([Si:11]([CH3:14])([CH3:13])[CH3:12])=[CH:8][CH:9]=[CH:10][C:2]=1[Cl:1])[CH3:16]

参加物

4

反応物 2

HCID 66970EthoxyethylamineHCID 151835572-Chloro-6-(trimethylsilyl)benzoyl chloride

生成物 1

HCID 18630026N-(2-ethoxyethyl)-2-chloro-6-(trimethylsilyl)benzamide収率 66.2%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

The compound of Example b (4.94 g, 20 mmol), 2-ethoxyethyl amine (3.92 g, 44 mmol), and toluene (35 mL) were combined according to General Method E1. The crude product was recrystallized from aq ethanol to afford 3.97 g of N-(2-ethoxyethyl)-2-chloro-6-(trimethylsilyl)benzamide as white solid, a 66% yield. m.p. 71-73° C.

後処理

  1. customThe crude product was recrystallized from aq ethanol

出典と根拠

ORDレコード
ord-7c7469ef38f34e528b1eecd2407de8d7
出典データセット
uspto-grants-2000_10
特許番号
US06133252

関連ノート

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