Carbon Dioxide → 4-Bromo-3-thenoic acid
反応式
Br[C:2]1[C:6]([Br:7])=[CH:5][S:4][CH:3]=1.[Li]C(C)(C)C.[C:13](=[O:15])=[O:14]>CCOCC.CCCCC>[Br:7][C:6]1[C:2]([C:13]([OH:15])=[O:14])=[CH:3][S:4][CH:5]=1参加物
6
反応条件
- 温度
- -78 °C
実験手順
To a solution of 3,4-dibromothiophene (15 g, 62 mmol) in 80 mL ether under a positive nitrogen atmosphere was added dropwise 75 mL 1.7M t-BuLi in pentane at below -73° C. and the resulting reaction solution was stirred at -78° C. for 0.5 h. After that, the ether solution was poured into dry ice and extracted with water. The aq solution was washed with ether and then acidified with concentrated HCl. The solid was filtered and air-dried to give 9 g of 4-bromo-3-thiophenecarboxylic acid, yield 70.3%.
後処理
- customthe resulting reaction solution
- extractionextracted with water
- washThe aq solution was washed with ether
- filtrationThe solid was filtered
- customair-dried
出典と根拠
- ORDレコード
- ord-6212e6e68c5b487ea0df8610456e50d7
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06133252
反応ノート
読み込み中…