Sodium Hydroxide → 2-Chloro-1,3-thiazole-4-carboxylic acid

HRID 368686ノート

反応式

HRID 368686 の反応式
[OH-].[Na+].C([O:5][C:6]([C:8]1[N:9]=[C:10]([Cl:13])[S:11][CH:12]=1)=[O:7])C>C(O)C>[Cl:13][C:10]1[S:11][CH:12]=[C:8]([C:6]([OH:7])=[O:5])[N:9]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 13106141Ethyl 2-chlorothiazole-4-carboxylate

生成物 1

HCID 218030262-Chloro-1,3-thiazole-4-carboxylic acid収率 61.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of NaOH (1.9 g, 47.5 mmol) and ethyl-2-chloro-4-thiazolecarboxylate (7.6 g, 40 mmol) in 100 mL absolute ethanol was stirred at RT for 4 h. After that, ethanol was removed in vacuo and the residue was dissolved in water. The aq layer was washed with ether and then acidified with conc HCl. The solid was filtered and air dried to give 4 g of 2-chloro-4-thiazolecarboxylic acid.

後処理

  1. customAfter that, ethanol was removed in vacuo
  2. dissolutionthe residue was dissolved in water
  3. washThe aq layer was washed with ether
  4. filtrationThe solid was filtered
  5. customair dried

出典と根拠

ORDレコード
ord-f59266bf3c414010b3d766565c3ded01
出典データセット
uspto-grants-2000_10
特許番号
US06133252

反応ノート

読み込み中…