Water → Isonicotinamide

HRID 368809

反応式

HRID 368809 の反応式
[C:1]([C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1)#[N:2].[OH2:9]>O1CCCC1>[N:6]1[CH:7]=[CH:8][C:3]([C:1]([NH2:2])=[O:9])=[CH:4][CH:5]=1

参加物

4

反応物 2

HCID 962WaterHCID 75064-Cyanopyridine

生成物 1

HCID 15074Isonicotinamide収率 91.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

(0.0051 g, 0.0119 mmol) of the platinum complex, prepared as in Example 1, was stirred with 4-cyanopyridine (2.0 g, 0.019 mol) and 0.75 ml (0.042 mol) of water and 10 ml tetrahydrofuran and the mixture heated under reflux for 4 hours. After cooling the liquids were removed using a rotary evaporator to give pyridine 4-carboxamide (2.12 g) corresponding to 90% yield.

後処理

  1. custom(0.0051 g, 0.0119 mmol) of the platinum complex, prepared as in Example 1
  2. temperaturethe mixture heated
  3. temperatureunder reflux for 4 hours
  4. temperatureAfter cooling the liquids
  5. customwere removed
  6. customa rotary evaporator

出典と根拠

ORDレコード
ord-abe4130096944c17b8c663f5db1a3233
出典データセット
uspto-grants-2000_10
特許番号
US06133478

関連ノート

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