Methyl 2-(3-hydroxyprop-1-yn-1-yl)benzoate → Methyl 2-(3-hydroxypropyl)benzoate
反応式
[OH:1][CH2:2][C:3]#[C:4][C:5]1[CH:14]=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8].[H][H]>CO.[Pd]>[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:14]=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8]参加物
5
実験手順
Step 2--A mixture of methyl o-(1-hydroxy-2-propyn-3-yl)benzoate (CXIX, 5.91 g) in methanol (60 ml) is hydrogenated at 40 psi hydrogen for 9 hrs using a total of 900 mg. Palladium on carbon (10%) is added in equal portions three times during the course of the reaction. The reaction is filtered and concentrated to give the saturated ester, methyl o-(1-hydroxyprop-3-yl)benzoate (CXXI).
後処理
- filtrationThe reaction is filtered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-e0de1580f71946f48cc1c4c8def22125
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06133446
反応ノート
読み込み中…