Ethyl trifluoroacetate → 1-(6-Fluorobenzothiazol-2-yl)-4,4,4-trifluorobutane-1,3-dione

反応式

C[O-].[Na+].[F:4][C:5]([F:12])([F:11])[C:6]([O:8]CC)=O.[C:13]([C:16]1[S:17][C:18]2[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:19]=2[N:20]=1)(=[O:15])[CH3:14]>C1COCC1>[F:25][C:23]1[CH:22]=[CH:21][C:19]2[N:20]=[C:16]([C:13](=[O:15])[CH2:14][C:6](=[O:8])[C:5]([F:4])([F:11])[F:12])[S:17][C:18]=2[CH:24]=1

参加物

実験手順

To a suspension of sodium methoxide (0.581 mg, 1.08 mmol) in THF (15 ml) was added a solution of ethyl trifluoroacetate (1.456 g, 10.2 mmol) in THF (7 ml) under nitrogen atmosphere. To the resulting mixture was added a solution of 2-acetyl-6-fluorobenzothiazole (2.00 g, 10.2 mmol) in THF (25 ml) dropwise along with ice cooling. The mixture was stirred at room temperature for 1.5 hours, and then concentrated. The resultant residue was subjected to purification using column chromatography on silica gel to afford 1-(6-fluorobenzothiazol-2-yl)-4,4,4-trifluorobutane-1,3-dione (1.26 g, 42%). NMR(CDCl3 -DMSO-d6) δ: 6.85 (1H, s), 7.23 (1H, app dt, J=2.6 Hz, 8.9 Hz), 7.59 (1H, dd, J=2.6 Hz, 8.2 Hz), 8.05 (1H, dd, J=4.6 Hz, 8.9 Hz); mp 175-178° C.