Sodium Hydroxide → 4-(4H-1,2,4-triazol-4-yl)benzoic acid
反応式
[OH-].[Na+].[N:3]1[N:4]=[CH:5][N:6]([C:8]2[CH:18]=[CH:17][C:11]([C:12]([O:14]CC)=[O:13])=[CH:10][CH:9]=2)[CH:7]=1>C(O)C>[N:3]1[N:4]=[CH:5][N:6]([C:8]2[CH:9]=[CH:10][C:11]([C:12]([OH:14])=[O:13])=[CH:17][CH:18]=2)[CH:7]=1参加物
4
反応条件
- 温度
- 55 °C
実験手順
5.5 ml of a 5 N aqueous sodium hydroxide solution was added to a solution of 1.2 g of ethyl 4-(1,2,4-triazol-4-yl)benzoate in 15 ml of ethanol. The mixture was stirred at 50-60° C. for 1 hour. The reaction mixture was concentrated under reduced pressure. To the residue was added ice water. The mixture was made acidic with acetic acid. The resulting crystals were collected by filtration, water-washed, and dried to obtain 0.95 g of 4-(1,2,4-triazol-4-yl)benzoic acid as a white powder. Melting point: 300° C. or above.
後処理
- concentrationThe reaction mixture was concentrated under reduced pressure
- additionTo the residue was added ice water
- filtrationThe resulting crystals were collected by filtration, water-
- washwashed
- customdried
出典と根拠
- ORDレコード
- ord-4641222792614521b6e25879188d3357
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06136826
反応ノート
読み込み中…