Methylamine → HCID 23284793、化合物

HRID 369216ノート

反応式

HRID 369216 の反応式
[CH3:1][NH2:2].[NH2:3][C:4]1[C:5]([F:28])=[CH:6][C:7]([F:27])=[C:8]([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:22])=[C:17](F)[C:18]=3[Cl:20])[C:13](=[O:23])[C:12]([C:24]([OH:26])=[O:25])=[CH:11]2)[CH:9]=1>N1C=CC=CC=1>[NH2:3][C:4]1[C:5]([F:28])=[CH:6][C:7]([F:27])=[C:8]([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:22])=[C:17]([NH:2][CH3:1])[C:18]=3[Cl:20])[C:13](=[O:23])[C:12]([C:24]([OH:26])=[O:25])=[CH:11]2)[CH:9]=1

参加物

4

反応物 2

HCID 6329MethylamineHCID 108619991-(3-Amino-4,6-difluorophenyl)-8-chloro-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

生成物 1

HCID 23284793HCID 23284793、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A 40% aqueous solution (100 mg) of methylamine and 1-(5-amino-2,4-difluorophenyl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (100 mg) were added to pyridine (2 ml), and the mixture was stirred at room temperature for 2 hours. After the solvent was distilled off under reduced pressure, ethanol was added to the residue, and the mixture was left to stand overnight. Solids deposited were collected by filtration to obtain the title compound (40 mg) as a colorless powder.

後処理

  1. distillationAfter the solvent was distilled off under reduced pressure, ethanol
  2. additionwas added to the residue
  3. waitthe mixture was left
  4. waitto stand overnight
  5. filtrationSolids deposited were collected by filtration

出典と根拠

ORDレコード
ord-4ccf6755664042708f7d529fb37989c9
出典データセット
uspto-grants-2000_10
特許番号
US06136823

反応ノート

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