Methylamine → HCID 69958909、化合物
反応式
[Cl:1][C:2]1[C:3](F)=[C:4]([F:26])[CH:5]=[C:6]2[C:11]=1[N:10]([C:12]1[CH:17]=[C:16]([NH:18][CH3:19])[C:15]([F:20])=[CH:14][C:13]=1[F:21])[CH:9]=[C:8]([C:22]([OH:24])=[O:23])[C:7]2=[O:25].[CH3:28][NH2:29]>N1C=CC=CC=1>[CH3:9][NH2:10].[Cl:1][C:2]1[C:3]([NH:29][CH3:28])=[C:4]([F:26])[CH:5]=[C:6]2[C:11]=1[N:10]([C:12]1[CH:17]=[C:16]([NH:18][CH3:19])[C:15]([F:20])=[CH:14][C:13]=1[F:21])[CH:9]=[C:8]([C:22]([OH:24])=[O:23])[C:7]2=[O:25]参加物
4
実験手順
8-Chloro-6,7-difluoro-1-(2,4-difluoro-5-methylaminophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (200 mg) and a 40% aqueous solution (220 mg) of methylamine were added to pyridine (600 mg), and the mixture was stirred at room temperature for 5 hours. After the solvent was distilled off under reduced pressure, ethanol (1 ml) was added to the residue, and the mixture was stirred for 30 minutes. Deposits were collected by filtration and washed successively with ethanol and diisopropyl ether to obtain the title compound (92 mg) as a colorless powder.