Methylamine → 1-(6-Amino-3,5-difluoropyridin-2-yl)-6,8-difluoro-7-methylamino-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid

HRID 369231ノート

反応式

HRID 369231 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:20])=[C:15](F)[C:16]=3[F:18])[C:11](=[O:21])[C:10]([C:22]([OH:24])=[O:23])=[CH:9]2)[C:5]([F:25])=[CH:4][C:3]=1[F:26].[CH3:27][NH2:28]>N1C=CC=CC=1>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:20])=[C:15]([NH:28][CH3:27])[C:16]=3[F:18])[C:11](=[O:21])[C:10]([C:22]([OH:24])=[O:23])=[CH:9]2)[C:5]([F:25])=[CH:4][C:3]=1[F:26]

参加物

4

反応物 2

HCID 6329MethylamineHCID 221211661-(6-Amino-3,5-difluoropyridin-2-yl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

生成物 1

HCID 232846821-(6-Amino-3,5-difluoropyridin-2-yl)-6,8-difluoro-7-methylamino-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
40 °C

実験手順

1-(6-Amino-3,5-difluoropyridin-2-yl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (60 mg) and a 40% aqueous solution (110 mg) of methylamine were added to pyridine (1,160 mg), and the mixture was stirred at 40° C. for 16 hours. The solvent was distilled off under reduced pressure, and ethanol (1 ml) was added to the residue. Deposits were collected by filtration and washed successively with ethanol and diisopropyl ether to obtain the title compound (58 mg) as a colorless powder.

後処理

  1. distillationThe solvent was distilled off under reduced pressure, and ethanol (1 ml)
  2. additionwas added to the residue
  3. filtrationDeposits were collected by filtration
  4. washwashed successively with ethanol and diisopropyl ether

出典と根拠

ORDレコード
ord-6a15f65a343d4c7baec8f071fdfafde2
出典データセット
uspto-grants-2000_10
特許番号
US06136823

反応ノート

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