Methylamine → 1-(6-Amino-3,5-difluoropyridin-2-yl)-8-bromo-6-fluoro-7-methylamino-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid

HRID 369232ノート

反応式

HRID 369232 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:20])=[C:15](F)[C:16]=3[Br:18])[C:11](=[O:21])[C:10]([C:22]([OH:24])=[O:23])=[CH:9]2)[C:5]([F:25])=[CH:4][C:3]=1[F:26].[CH3:27][NH2:28]>N1C=CC=CC=1>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:20])=[C:15]([NH:28][CH3:27])[C:16]=3[Br:18])[C:11](=[O:21])[C:10]([C:22]([OH:24])=[O:23])=[CH:9]2)[C:5]([F:25])=[CH:4][C:3]=1[F:26]

参加物

4

反応物 2

HCID 6329MethylamineHCID 154869771-(6-Amino-3,5-difluoropyridin-2-yl)-8-bromo-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

生成物 1

HCID 232848271-(6-Amino-3,5-difluoropyridin-2-yl)-8-bromo-6-fluoro-7-methylamino-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

1-(6-Amino-3,5-difluoropyridin-2-yl)-8-bromo-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (200 mg) and a 40% aqueous solution (230 mg) of methylamine were added to pyridine (620 mag), and the mixture was stirred at room temperature for 2 hours. The solvent was distilled off under reduced pressure, and ethanol (2 ml) was added to the residue. Deposits were collected by filtration and washed successively with ethanol and diisopropyl ether to obtain the title compound (103 mg) as a colorless powder.

後処理

  1. distillationThe solvent was distilled off under reduced pressure, and ethanol (2 ml)
  2. additionwas added to the residue
  3. filtrationDeposits were collected by filtration
  4. washwashed successively with ethanol and diisopropyl ether

出典と根拠

ORDレコード
ord-a0addedc40024c69a6194a982d7f7219
出典データセット
uspto-grants-2000_10
特許番号
US06136823

反応ノート

読み込み中…