Potassium Nitrate → 1-Bromo-4-fluoro-5-methyl-2-nitrobenzene

HRID 369238

反応式

HRID 369238 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:9])=[C:6]([CH3:8])[CH:7]=1.[N+:10]([O-])([O-:12])=[O:11].[K+]>S(=O)(=O)(O)O>[Br:1][C:2]1[C:3]([N+:10]([O-:12])=[O:11])=[CH:4][C:5]([F:9])=[C:6]([CH3:8])[CH:7]=1

参加物

4

反応物 2

HCID 24434Potassium NitrateHCID 1235275-Bromo-2-fluorotoluene

生成物 1

HCID 232846641-Bromo-4-fluoro-5-methyl-2-nitrobenzene収率 104.5%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

5-Bromo-2-fluorotoluene (7.65 g) was added to concentrated sulfuric acid (40 ml), and potassium nitrate (4.2 g) was added portionwise to the mixture at -20° C. The temperature of the reaction mixture was given back to room temperature to conduct stirring for 3 days, and then poured into ice water to conduct extraction with ethyl acetate. After an organic layer was dried over anhydrous magnesium sulfate, the solvent was distilled off to obtain the title compound (9.9 g) as a pale yellow oil.

後処理

  1. additionwas added portionwise to the mixture at -20° C
  2. customwas given back to room temperature
  3. extractionextraction with ethyl acetate
  4. dry with materialAfter an organic layer was dried over anhydrous magnesium sulfate
  5. distillationthe solvent was distilled off

出典と根拠

ORDレコード
ord-6f2bc81ea0144785a0dd9ea6908bf2aa
出典データセット
uspto-grants-2000_10
特許番号
US06136823

関連ノート

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