1-Bromo-4-fluoro-5-methyl-2-nitrobenzene → 2-Bromo-5-fluoro-4-methylaniline

HRID 369239ノート

反応式

HRID 369239 の反応式
[Br:1][C:2]1[C:3]([N+:10]([O-])=O)=[CH:4][C:5]([F:9])=[C:6]([CH3:8])[CH:7]=1>C(O)(=O)C.[Fe]>[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([F:9])=[CH:4][C:3]=1[NH2:10]

参加物

4

反応物 1

HCID 232846641-Bromo-4-fluoro-5-methyl-2-nitrobenzene

生成物 1

HCID 27733792-Bromo-5-fluoro-4-methylaniline収率 93.4%

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 176Acetic Acid溶媒

反応条件

温度
70 °C

実験手順

Iron powder (18.5 g) was added to a solution of 5-bromo-2-fluoro-4-nitrotoluene (9.7 g) in acetic acid (30 ml), and the mixture was stirred at 70° C. for 3 hours. The catalyst was removed by filtration through Celite, and the filtrate was washed with chloroform. The solvent and the like in the filtrate were distilled off under reduced pressure. The residue was subjected to column chromatography on silica gel to conduct elution with chloroform, thereby obtaining the title compound (7.9 g) as a red oil.

後処理

  1. customThe catalyst was removed by filtration through Celite
  2. washthe filtrate was washed with chloroform
  3. distillationThe solvent and the like in the filtrate were distilled off under reduced pressure
  4. washelution with chloroform

出典と根拠

ORDレコード
ord-b35a5741b64740b282bda99be200b36e
出典データセット
uspto-grants-2000_10
特許番号
US06136823

反応ノート

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