Potassium Nitrate → HCID 23284719、化合物

HRID 369325ノート

反応式

HRID 369325 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:22])=[C:15]([N+:19]([O-:21])=[O:20])[C:16]=3[CH3:18])[C:11](=[O:23])[C:10]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:9]2)=[C:4]([CH3:29])[CH:3]=1.[N+:30]([O-])([O-:32])=[O:31].[K+]>S(=O)(=O)(O)O>[F:1][C:2]1[C:7]([N+:30]([O-:32])=[O:31])=[CH:6][C:5]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:22])=[C:15]([N+:19]([O-:21])=[O:20])[C:16]=3[CH3:18])[C:11](=[O:23])[C:10]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:9]2)=[C:4]([CH3:29])[CH:3]=1

参加物

4

反応物 2

HCID 24434Potassium NitrateHCID 23284684HCID 23284684、化合物

生成物 1

HCID 23284719HCID 23284719、化合物収率 89.9%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

Ethyl 1-(4-fluoro-2-methylphenyl)-6-fluoro-8-methyl-7-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate (1.1 g) was added to concentrated sulfuric acid (10 ml), and potassium nitrate (330 mg) was added to the mixture under ice cooling. The resultant mixture was stirred at room temperature for 4 days. The reaction mixture was poured into ice water and extracted with chloroform. A chloroform layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off to obtain the title compound (1.1 g) as a pale yellow amorphous substance.

後処理

  1. additionwas added to the mixture under ice cooling
  2. extractionextracted with chloroform
  3. dry with materialA chloroform layer was dried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off

出典と根拠

ORDレコード
ord-530f1049adc94f5e894da2bf7485d109
出典データセット
uspto-grants-2000_10
特許番号
US06136823

反応ノート

読み込み中…