Phenol → Methyl-4-(trans-2-decenyloxy)-benzoate

HRID 369532

反応式

HRID 369532 の反応式
C1(O)C=CC=CC=1.C(O)C=CCCCCCCC.CCOC(/N=N/C(OCC)=O)=O.[CH3:31][O:32][C:33](=[O:59])[C:34]1[CH:39]=[CH:38][C:37]([O:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50]CCCCCCCC)=[CH:36][CH:35]=1>CCOCC>[CH3:31][O:32][C:33](=[O:59])[C:34]1[CH:39]=[CH:38][C:37]([O:40][CH2:41]/[CH:42]=[CH:43]/[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH3:50])=[CH:36][CH:35]=1

参加物

6

反応物 4

HCID 996PhenolHCID 876302-Decen-1-olHCID 4189536Methyl 4-(octadecyloxy)benzoateHCID 5462977Diethyl azodicarboxylate

生成物 1

HCID 18521070Methyl-4-(trans-2-decenyloxy)-benzoate収率 65%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

Phenol 34 (486 mg, 3.2 mmol), 2-decenol 26 g (500 mg, 3.2 mmol), TPP (965 mg, 3.68 mmol), and DEAD (641 mg, 3.68 mmol) in 32 ml ether were reacted according to the procedure for compound 35a. The crude product was purified via flash chromatography over silica gel with gradual elutions from 95/5-90/10 (v/v, Hex/EtOAc). Evaporation of solvent yielded 603 mg (65%) of colorless needles.

後処理

  1. customThe crude product was purified via flash chromatography over silica gel with gradual elutions from 95/5-90/10 (v/v, Hex/EtOAc)
  2. customEvaporation of solvent

出典と根拠

ORDレコード
ord-18a140bcba8640bf90b50ad97f4e25ab
出典データセット
uspto-grants-2000_10
特許番号
US06139771

関連ノート

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